Ligandrol (LGD-4033)

Anabolicum, a name that has enjoyed the spotlight for more than one occasion. Also known as Ligandrol or LGD-4033, this substance is going to be the subject of this article so if you want to learn more about it, be sure to read through towards the end of this article.

What Studies Say

The very first instance that it was featured in the press is when it was taken to Phase 1 of clinical human trials and produced some spectacular results.

In the study, there were 70 healthy individuals who were subjected to the substance and were randomized with placebo. The gain in lean muscles observed in every one of them was very surprising and this happened without any variation in the levels of Prostate Specific Antigen.

According to Boston University School of Medicine’s Associate Professor and Director of Androgen Clinical Research Unit Shehzad Basaria, LGD-4033 has a great potential of becoming a high-quality molecule in the aspect of muscle loss and muscle wasting. This is one of the arenas in medicine which badly needs new medicines.

He is also a co-principal investigator in Phase 1 of LGD-4033’s study on multiple ascending dosages.

The Case of Will Grier

Just a few years after the study was published, a quarterback from Florida named Will Grier was able to gain 43 lbs of muscle in just 1 year. It’s not just ordinary muscle, it is lean and rock-solid muscle! Investigations have revealed that he was using LGD-4033 which he called a type of those “over the counter” supplements in one of the press conferences that he attended.

This has caused him to be banned for a year but the press always tends to be good towards SARMs. Enough has been seen by skeptics, naysayers, SARMs buffs and even the average gym rat. They now know that LGD-4033 is for real!

Even without the fast muscle gain, Will Grier was already invincible when put on the field. He had a record of a whopping 1202 yards with 12 touchdowns and 2 interceptions just in the first half of the season!

What Exactly is LGD-4033

Anabolicum which is otherwise known as Ligandrol or LGD-4033 is a chemical used in research and was developed by Ligand Pharmaceuticals. It was intended for some therapeutic applications because of its ability to prevent muscle wasting that comes as a result of cancer and it can also counter the increase of diminished bone density in osteoporosis due to certain medications. It is also capable of preventing muscle loss because of aging.

It is a SARM or Selective Androgenic Receptor Modulator which efficiently binds with the androgen receptors that are found in the bone and muscle tissues and leaves the receptors in the reproductive system, prostate, and those found in the endocrine system untouched.

In the long run, Viking was able to take over the research that is why LGD-4033 is also called VK5211 in some places. This substance often comes along with MK-2866 or Ostarine which happens to be one of the most popular SARM among those who are in the area of bodybuilding.

It is even considered as one of the SARMs that beginners should take especially in their first cycle because it is well tolerated. It’s available got an excellent bioavailability and offers some good results that can be compared to what standalone Enanthate steroids and Testosterone supplements can produce.

How It Works

Ligandrol (LGD-4033) exhibits a strong affinity for Selective Androgenic Receptors that bind themselves to the tissues of the muscles and bones. It does so without affecting the liver and sebaceous glands.

While mimicking the androgen receptor’s effects, Ligandrol gives the user the ability to gain strength, lose fat, recover faster from injury, and the most favorite of all, gain lean muscles! When these are achieved, an improvement in the overall quality of life would be the end result.

Gym buffs would love the increase in muscle mass that the substance is capable of producing as one of its effects but athletes mostly focus on the strength and fast recovery from an injury that LGD-4033 provides.

The substance is listed as banned by WADA so if you’re a professional athlete, the long detection time and half-life of Ligandrol is definitely a great concern not to mention that the fast gain of up to 40 lbs. of muscles would surely ring some bells!

The Known Effects of LGD-4033

People are quick to compare LGD-4033’s effects to that of testosterone but that’s something that’s more of a broad comparison.

LGD 4033 can help in cutting, bulking and recomposition makes it perfect for those who want to achieve their bodybuilding goals. The substance has a well-rounded profile and it pairs perfectly with other SARMs. It also complements every kind cycle on Anabolic Steroids.

Below are Ligandrol’s applications in different bodybuilding goals.


LGD-4033 shows some great results, especially in the bulking cycle. Stacking it with other SARMs is no longer needed. There are those who stack it with Testolone but precautions must be observed because this can lead to water retention. However, bloating will not show up as a side effect. It is, therefore, a good standalone SARM which can give you the craziest pumps that you have ever experienced!


During the cutting cycle, the preventive action of muscle loss in LGD-4033 will give you enough ability to retain the ones you’ve gained. However, if you’re on a severely restrictive diet especially on calories and you are looking for extra support, you can stack it with Cardarine.

Body Recomposition:

If it’s body recomposition that you want, Ligandrol can be stacked with Cardarine in order to produce such results. Consider it as an AAS stack with Test-E being the base with Masteron and Anavar. It is going to give you some lean and hard muscles that looks great with very minimal water retention. And with its enhanced fat burning abilities, it is going to give you the look that’s ready for any bodybuilding competition!

Recovery and Overall Well-Being:

Just like any other SARM, Ligandrol tends to show some positive effects on the tendons, ligaments, and joints. Recovery from injuries would be faster even after some heavy exercise sessions with very minimal stress on the joints. There are users who also reported an improved mood and focus while getting a consistent flow of energy while using Ligandrol.

How to Use Ligandrol

If you’re on a cycle of body recomposition, a low dose of just 10mg per day is going to give you some great results. A 4-6 weeks cycle is recommended because the body builds a tolerance towards it after 6 weeks.

To bodybuilders who want to bulk up, even a 25mg of dosage per day is going to be tolerated by the body with very minimal side effects. Just be sure to limit this to a 4-week cycle to get the best results and minimum risk of suppression.

There are accounts and claims that they used up to 40mg per day without experiencing side effects but we don’t recommend going this high unless it is your fourth or fifth Ligandrol cycle.

What Are the Possible Side Effects of Ligandrol?

At 22mg of dosage per day, LGD-4033 has shown very minimal side effects at dosing in the short term.

Side effects are very mild that it’s even hard to notice them and they usually go away after discontinued use. Users report dryness in the mouth while others experienced very mild headaches.

But it’s important to note that even a dosage of 1mg per day can cause mild suppression. This means that when Ligandrol is used at high dosage for longer durations like 40mg per day for 8 weeks, it can partially shut you down which would require a full-fledged PCT to recover.

Estrogen-related side effects will also be avoided because Ligandrol does not aromatize as some exogenous testosterone do. There will also be no liver toxicity, swollen prostate or baldness that user would experience.


Ligandrol or LGD-4033 is one of those SARMs that are safest to use. It is well suited for those who have some serious fitness and bodybuilding goals. But its long term effects are still unknown so use it safely in the short term following the recommended dosage and you should be able to achieve great gains with very minimal side effects!